Damage Types

There are a few set damage types in the game. Pretty much everything will have a specific set of strengths and weaknesses.

Physical damage types:

Slashing: Common damage dealt by blades. More effective against fleshy targets.

Blunt: Unarmed attacks, gloves, maces, and slam attacks. Great against things like skeletons.

Piercing: Teeth (wolf) and some special attacks deal this damage. More effective against large targets.

Ranged: Bows and throwables. Deals extra damage to flying things.

Silver: A special damage type that is particularly effective vs shape shifters and undead.

Magic damage types:

Fire: Deals huge damage. Very effective against snow dwelling creatures or flammable things (like mimics, the evil treasure chests).
Water: Ice blasts deal modest damage at a more affordable mana cost. It kills what fire can't.

Air: Deals more damage against flying enemies and less against burrowing ones.

Earth: Anything not weak against the other three elements is probably weak to this one.

Holy: Great for banishing demons and destroying undead. Not effective against Mystics.

Psionic: Very effective against spirits and magic beings. Not effective against constructs.

Dark: Corrupts and destroys all natural life. Not effective against hell-spawn.